Glymphatic clearance to alleviate brain edema and Alzheimer's pathology in mice

ersinesen 15 hours ago
Noninvasive ultrashort wave neuromodulation enhances glymphatic clearance to alleviate traumatic brain edema and Alzheimer’s pathology
awakeasleep 15 hours ago
The idea of getting a brain cleaning like this sounds so appealing to me
- flotzam 14 hours ago
  There's an animated visual pattern that induces this cerebrospinal fluid flow: https://news.ycombinator.com/item?id=41942775
  I've found it helpful for getting rid of the frazzled feeling after a sleepless night.
khelavastr 14 hours ago
This is obvious since undertranscribed CRHR2 region means undertranscribed AQP1 to trigger cellular glymphatic release, as well as undertranscribed INMT to trigger DMT-class dreaming and neuroflexibility.
Eventuakly this downregulates the pseudoautosomal region and xq28, including melatonin-ptoducing ASMT/ASMTL, renin-angiotensin-aldosterone-regulating AVPR2, neuroimmune and inflammation regulating IL3R and IL9R, and more.
Alzheimer's and BRCA-mediated breast cancers share triggers because BRCA1 (breast cancer associated 1) is in the same region and CRHR1 (corticotropin rlreasing hormone receptor 1) and MAPT (tau protein)
- JumpCrisscross 14 hours ago
  Am I missing the takeaway or is this slop?
RobotToaster 13 hours ago
What sort of device is used for this? It isn't really clear.
measurablefunc 14 hours ago
I think cardio exercise does the same thing.
- rzzzt 14 hours ago
  Long-term physical exercise facilitates putative glymphatic and meningeal lymphatic vessel flow in humans: https://pmc.ncbi.nlm.nih.gov/articles/PMC11982307/
  - meristohm 11 hours ago
    Abstract: Regular voluntary exercise has been shown to increase waste transport through the glymphatic system in mice. Here, we investigate the impact of physical exercise on both upstream and downstream brain waste clearance in healthy volunteers via noninvasive MR imaging. Putative glymphatic influx, evaluated using intravenous contrast-enhanced dynamic T1 mapping, increases significantly at the putamen after 12 weeks of long-term exercise using a cycle ergometer. The putative meningeal lymphatic vessel size and flow, measured by intravenous contrast-enhanced black-blood imaging and IR-ALADDIN technique, increase significantly after long-term exercise. Plasma proteomics reveals significant changes in inflammation-related and immune-related proteins (down-regulated: S100A8, S100A9, PSMA3, and DEFA1A3; up-regulated: J chain) after long-term exercise, which correlate with putative glymphatic influx or mLV flow. Our results suggest that increased glymphatic and mLV flow may be the potential mechanism underlying the neuroprotective effects of exercise on cognition, highlighting the importance of long-term, regular exercise.
  - Melatonic 8 hours ago
    I wonder if manual lymphatic drainage or those pressure things on your legs that runners use could help people that can't exercise as much